WITHDRAWN: IL-22 in liver inflammation, injury and repair

22-P013 – Withdrawn

Xenopus model. It provides wild-type, transgenic and mutant frogs to research labs at cost and can now also supply oocytes, embryos and frozen sperm. All of the GA animals are quality controlled to ensure that their offspring have the expected phenotype. In addition to these animal resources EXRC is gathering insitu hybridisation probes, relevant antibodies and expression clones from labs; agai...

Acetaminophen-Induced Liver Injury Acute and Chronic Effects of IL-22 on

Roles of IL-22 in Allergic Airway Inflammation

IL-23- and IL-17A-producing CD4(+) T cell (Th17 cell) axis plays a crucial role in the development of chronic inflammatory diseases. In addition, it has been demonstrated that Th17 cells and their cytokines such as IL-17A and IL-17F are involved in the pathogenesis of severe asthma. Recently, IL-22, an IL-10 family cytokine that is produced by Th17 cells, has been shown to be expressed at the s...

IL-22 Promotes Fibroblast-Mediated Wound Repair in the Skin

Skin wound repair requires complex and highly coordinated interactions between keratinocytes, fibroblasts, and immune cells to restore the epidermal barrier and tissue architecture after acute injury. The cytokine IL-22 mediates unidirectional signaling from immune cells to epithelial cells during injury of peripheral tissues such as the liver and colon, where IL-22 causes epithelial cells to p...

Infiltrating monocytes in liver injury and repair

Noninfectious liver injury causes many acute and chronic liver diseases around the globe, and particularly in developed nations. Bone marrow-derived monocytes infiltrate the damaged liver tissue and are a critical component of the innate immune response that may drive injury resolution or host death in the short term or chronic inflammation, fibrosis and hepatocellular carcinoma in the long ter...